The invention discloses a ginsenoside CK preparation method. According to the present invention, ginsenoside CK is prepared by using a mixed acid hydrolysis method, wherein the ginsenoside CK with thecontent of more than 98% is prepared through preparation of the total saponin of the leaves of Panax notoginseng, preparation of ginsenoside CK, purification and other steps; the conversion efficiency of the method is high, the conversion product is easily separated so as to remove the impurity, and the ginsenoside CK crude product with the content of more than 90% can be obtained by using the simple solvent treatment, such that the disadvantage that the ginsenoside CK can be obtained by repeatedly using the silica gel column and gel column chromatography method is avoided; and the method hasadvantages of low cost and high efficiency, and is suitable for industrial production and marketing application.