The invention relates to an anti-interference method based on combined N-ary spread spectrum and multi-carrier modulation. Through utilization of an N-ary spread spectrum technology, anti-interferenceperformance of unmanned aerial vehicle data links in a complex electromagnetic environment is improved. Through utilization of a multi-carrier technology, multichannel high speed transmission of information is realized. A result shows that according to the method, the anti-interference performance of the unmanned aerial vehicle data links in the complex electromagnetic environment can be effectively improved