The invention discloses a method of producing calligraphy from medical stone and tourmaline. According to the method, raw materials are soaked in a prepared soaking solution, then an anticorrosion treatment, a mould proof treatment, an insect bite control treatment, and a fading resisting treatment are carried out, the raw materials are grinded into powder, and finally three-dimensional calligraphy is prepared from the powder smartly. The calligraphy can be placed in a room, is capable of slowly releasing negative ions, has a health care effect on human body through the breathing effect, and has an especially good effect on people having symptoms such as neurasthenia, amnesia, insomnia, palpitation, and the like. The method is innovative and scientific, and prepared calligraphy is practical, three dimensional, natural, and vivid, is resistant to mould, insects, and deformation, and can be preserved for a long term.