The invention provides a high corrosion resistance titanium alloy and a preparation method of the high corrosion resistance titanium alloy. The titanium alloy is prepared from, by mass, 2.0-3.5% of Al, 50% or less of Zr, 1.5-3.0% of V and the balance Ti. The content of the elements is strictly controlled, the mechanical property of the titanium alloy is improved, the titanium alloy has the excellent corrosion resistance in the most media such as acid, base and salt due to adding of Zr, meanwhile, the mechanical property of the alloy can be improved through a solution strengthening and refinedcrystalline strengthening mechanism, and Zr has an obvious performance complementing and improving effect on the Ti alloy. Experiment results show that the tensile strength of the high corrosion resistance titanium alloy is improved by 122.5% compared with traditional titanium alloy, and corrosion resistance is improved by 71.07% compared with traditional titanium alloy.