The invention discloses a rock core recrystallization infiltration device and an experimental method and belongs to the field of oil and natural gas underground reserves. The device includes a model device and a control device. The model device includes a liquid storage tank and a rock core holder. The bottom of the liquid storage tank is connected to the rock core holder. The liquid storage tankis used for holding a recrystallization liquid, and the rock core holder is used for holding the rock core. The control device includes a pressure control module and a temperature control module. Thepressure control module is respectively connected to the liquid storage tank and the rock core holder and is used for controlling the hydrostatic column pressure above the liquid storage tank and applying confining pressure and axial pressure to the rock core. The temperature control module is used to control the temperature of the rock core. The rock core recrystallization infiltration device caneffectively simulate the recrystallization plugging process of the salt rock, so as to further evaluate the plugging effect of the salt hole recrystallization.