The present invention relates to the field of oxygen supply, especially to a high-altitude area oxygen supply method and system. The method is applied to an oxygen supply device. The oxygen supply device comprises a processor, a heart rate sensor, an oxygen source, an oxygen valve, an air valve, a mix chamber and an oxygen supply mask. The mix chamber communicates with the oxygen source through the oxygen valve; the mix chamber communicates with an atmospheric environment through the air valve; and the oxygen supply mask communicates with the mix chamber. The method comprises the steps that: the processor obtains a current oxygen content; the processor obtains heart rate parameters of an oxygen object through the heart rate sensor; the processor determines the oxygen supply content according to the heart rate parameters; and the processor controls the opening of the oxygen valve and the opening of the air valve according to the current oxygen content and the oxygen supply oxygen content. The high-altitude area oxygen supply method and system can adaptively regulate the oxygen supply oxygen content according to the oxygen supply demand of the oxygen supply object at the high-altitude area.