The invention provides a load protection circuit and an air conditioner and relates to the technical field of a switching power source. The load protection circuit includes a voltage detection moduleand a switch module, and the voltage detection module is electrically connected to the switch module; the voltage detection module is configured to enter a self-locking state when received first inputvoltage is greater than or equal to a preset voltage protection threshold value to keep the switch module in an off state; as the voltage of a three-phase electric current is higher than the voltageof a single-phase electric current, the first input voltage received via the voltage detection module is greater than or equal to the preset voltage protection threshold value when the three-phase electric current is misconnected, thus the voltage detection module enters the self-locking state, no voltage signal is output, a controller can be prevented from being damaged when the three-phase electric current is misconnected, the switch module can be prevented from having working voltage, thus a disconnected state can be maintained so as to cut off the connection between the power source and aload motor, and that the load motor cannot be damaged can be ensured.