The embodiment of the invention discloses an interference processing method and device. The interference processing method in the embodiment of the present invention includes that: a near field communication (NFC) card reader sends a request instruction; when the NFC card reader receives a modulated signal and fails to decode the modulated signal, the modulated signal is matched with a preset condition to obtain a matching result; and the NFC card reader selects whether to send an error indication instruction according to the matching result. The embodiment of the invention solves the problemthat the card reader is difficult to be compatible with high reliability and high sensitivity in the NFC technology.