The invention discloses a high-accuracy prediction method and device. The method comprises the steps: performing five consecutive first-order inertial inverse operations of a to-be-processed signal through a preset first-order inertia inverse operation formula; solving the sum of a first output signal, a second output signal, a third output signal, a fourth output signal and a fifth output signal;performing the fifth-order inertia operation of the sixth output signal through a preset fifth-order inertia operation formula; performing five consecutive first-order inertia operations of the eighth output signal through a preset first-order inertia operation formula; multiplying a thirteenth output signal by a preset first constant of 0.1; solving the sum of the ninth to fourteenth output signals; multiplying the output signal of the subtraction by a preset second constant of 1.02 to obtain a high-accuracy predicted output signal. The method and device solve the technical problems that theMPC has insurmountable defects in an uncertainty problem and the setting of more coupling models may cause the control system to be complicated.