Systems, methods, and computer readable media to improve the development of image processing intensive programs are described. In general, techniques are disclosed to non-intrusively monitor the run-time performance of shader programs on a graphics processing unit (GPU)—that is, to profile shader program execution. More particularly, the shader profiling comprises of sampling data during the execution of a compiled code on GPU. The execution duration of the sequences of instructions within the code is determined. Subsequently, based relative latency of the instructions within the sequence, the duration time for each binary instruction is determined. The binary instructions are then mapped to source code in order to obtain the amount of time each source code instruction in a shader take to execute per draw call.