The invention discloses an anti-wind, anti-pressure and anti-quake connection device for a double-joined wood beam and supporting steel columns, which comprises the double-joined wood beam, the supporting steel columns, a vertical connector and a transverse connector, wherein the vertical connector vertically passes through the middle of the double-joined wood beam; the lower part of the verticalconnector is connected with the supporting steel columns; the transverse connector transversely passes through the middle of the double-joined wood beam; and the vertical connector and the transverseconnector are dislocated and cross-shaped spatially, that is, are not in the same vertical plane. As the vertical connector and the transverse connector are arranged, the double-joined wood beam is fastened in multiple directions, the connection between the double-joined wood beam and the supporting steel columns is firm and reliable, the anti-wind, anti-pressure and anti-quake stress needs are met, and the structure can be ensured to be stable for a long time.