The invention relates to the field of creep feed and particularly discloses a premix capable of reducing the usage amount of zinc oxide in creep feed and the creep feed. The premix contains a soybeantrypsin inhibiting factor, lentinan and glucose, the mass percentage of the soybean trypsin inhibiting factor in the premix is 1%-5%, and the mass percentage of the lentinan in the premix is 20%-50%.The premix is used for preparing the creep feed for piglets. The creep feed for the piglets is prepared from basic feed, zinc oxide and the premix, and the feeding period starts from the 14th day after born of the piglets to the 10th day after weaning. By use of the premix, firstly, the disease resistance and diarrhea resistance of the piglets can be improved under the stimulation effect of the low-dosage anti-bacterial factor, the usage amount of exogenous zinc oxide can be decreased significantly, the emission of zinc elements in an animal breeding process can be effectively reduced, and theecological environment is further protected; and secondly, the premix has remarkable promoting functions on improving growth performance of the piglets and reducing the diarrhea rate of the piglets.