The invention relates to a full-automatic marble sand-blasting device. The full-automatic marble sand-blasting device comprises an air bin, a sand bin, a mixing pipe, a negative pressure pump, a spraybed, movable partition plates, a first cylinder, a first air rod, a second cylinder, a second air rod, a first movable block, a second movable block, a sand discharging pipeline and a sand collectionbox. The full-automatic marble sand-blasting device is characterized in that the sand bin is located in the air bin, a first electromagnetic valve is arranged below the sand bin, a connection air pipe is arranged outside the air bin and connected with the negative pressure pump, the connection air pipe is provided with a second electromagnetic valve, one end of the mixing pipe is connected with the air bin, the other end of the mixing pipe is installed in the spray bed, the mixing pipe is provided with a manual valve, the spray bed is provided with a movable tank, a first sliding groove and asecond sliding groove are formed in one end of the spray bed and provided with the movable partition plates, and sand via holes are formed in the movable partition plates. Through arrangement of thefull-automatic marble sand-blasting device, the sand blasting efficiency is improved, large-area sand blasting is achieved, and meanwhile the dust removal effect is achieved.