The invention discloses a novel manual binding machine with a punching mechanism. The novel manual binding machine comprises a machine body, and a first cavity and a second cavity formed in the machine body. A third cavity is formed in the top wall of the first cavity. Fourth cavities extending downwards are formed in the left and right end walls of the third cavity. Fifth cavities are formed between the fourth cavities and the third cavity. A threaded sleeve extending up and down is rotatably arranged between the third cavity and the first cavity. A first bevel gear is fixedly mounted at thetail end of the top of the threaded sleeve in the third cavity. The first bevel gear is fixedly connected with a motor output shaft fixedly arranged in the top wall of the third cavity. Structure is simple and operation is convenient. One power source is adopted to drive equipment punching and pressing shaping. Adjustment is convenient, punching efficiency and fastening quality are improved, working procedures are matched with each other and are not influenced, and the practical performance of the device is improved.