The invention discloses a graft adhesive pressure-filling machine. The graft adhesive pressure-filling machine comprises a base plate. Supporting legs are mounted at the four corners of the bottom surface of the base plate. Rubber suction cups are mounted at the bottom ends of the supporting legs. Two supporting columns are mounted on the base plate. A top plate is mounted on the supporting columns. A reaction kettle is mounted on the inner sides of the supporting columns. A heating base is mounted on the outer surface of the lower portion of the reaction kettle. Electric heating bars are mounted on the upper end face of the heating base. First supporting columns are mounted on the bottom surface of the heating base and are fixed to the heating base through welding. A motor protection shell is mounted on the upper end face of the reaction kettle. A feeding pipe is mounted on one side of the motor protection shell and penetrates through the top plate to extend to the position above thetop plate. A feeding port is formed in the top end of the feeding pipe. By adoption of the graft adhesive pressure-filling machine, the product quality can be effectively improved in the graft adhesive production process, and the situation that graft adhesives are scrapped due to solidification in the pressure-filling packaging process is effectively avoided.