The invention relates to a new mildew-resistant wood-plastic material. The wood-plastic material is prepared from, by weight, 22 parts of mulberry tree powder, 2 parts of hollow microspheres, 22 partsof reed straws, 6 parts of rigid package paper powder, 17 parts of Trichosanthes kirilowii vines, 17 parts of bamboo powder, 20 parts of waste packaging bag plastic pellets, 22 parts of polypropylene, 22 parts of polyvinyl chloride, 4 parts of nanometer titanium dioxide, 3 parts of nanometer zirconium dioxide, 2 parts of palygorskite, 2 parts of nanometer molybdenum disulfide, 2 parts of softwoodfibers, 0.6 part of magnesium hydroxide, 0.2 part of expandable graphite, 2 parts of dioctyl phthalate, 3 parts of polyethylene glycol distearate, 2 parts of phenolic resin, 3 parts of polyethylene wax, 4 parts of suberosin and 0.2 part of chlorothalonil. The wood-plastic material is simple to manufacture, has good economical and environmentally-friendly properties, and fully utilizes waste woodand plastics to reduce the environmental pollution; the material has good compactness and good mechanical properties, so the material is very durable; and the material has good mildew-resistant and antibacterial properties, so the material has wide application values.