The invention provides a production process of a waterproof multi-layer composite corrugated board, and relates to the technical field of corrugated board production and processing. The waterproof multi-layer composite corrugated board production process comprises the following steps: preparation, screening, pulping, mixing, pressing, drying, hot pressing, corrugated pressing, laminating, gluing,coating, drying, shaping, line pressing, cooling and other steps. According to the production process of the waterproof multi-layer composite corrugated cardboard, by adding graphene into paper makingpulp and by a hot pressing process, the compressive strength of the corrugated board can be effectively increased; by adding plastic powder into the paper making pulp, the defect that corrugated paper is easily collapsed by water is reduced, and at the same time, in the manufacturing process of the corrugated cardboard, a surface paper layer is coated with a waterproof film, thus further improving the waterproof property of the corrugated cardboard.