The invention discloses a method for coping with well leakage in deep water drilling operation, comprising the following steps: S1, measuring the leak rate; S2, drilling to a tube shoe; S3, reducing the specific gravity of mud in a waterproof pipe to enable the pressure in the waterproof pipe to be higher than the formation pressure; S4, switching off an annular blowout preventer, isolating a wellbore, performing circulation with a drilling fluid with reduced specific gravity for 1.5 to 2 weeks until no trapped gas is displayed, switching on the annular blowout preventer, monitoring the wellbore level, and if there is still leakage, performing a step S5; S5, establishing circulation: switching off the annular blowout preventer, establishing circulation with small emission, pumping a leakage stoppage drilling fluid, if it returns to normal, resuming normal operation, otherwise, performing a step S6; S6, changing drilling tools and performing strong plugging: replacing with conventionaldrilling tools, switching off a variable ram-type blowout preventer, performing circulation for 2 week unit there is no trapped gas, pumping plugging mud, periodically monitoring the wellbore, and ifit returns to normal, resuming normal operation. The method has the advantages of being simple in operation, easy to grasp, good in formula plugging effect and easy in configuration, and can be widelyapplied in the field of deep water drilling.