The invention aims at providing an efficient-absorption snake gourd seed processing method. The snake gourd seed processing method comprises the following steps: (1) selecting snake gourd seeds with full kernels into an activated saccharomycetes mixed solution and immersing for 10 to 15min; then washing by utilizing a flowing washing solution; (2) then putting the washed snake gourd seeds into a vacuum humidification box and carrying out humidification and softening treatment; (3) carrying out drying and dehydration treatment on the snake gourd seeds softened in step 2; then pouring the seedsinto medicated wine which is prepared in advance and immersing for 1 to 2h to obtain expanded and efficient-absorption snake gourd seeds. By adopting the method provided by the invention, the snake gourd seeds are more sufficiently permeated when being immersed for eating, the immersion effect is improved, the medical effect is improved, the utilization rate of the snake gourd seeds is improved and the wastes of the snake gourd seeds are effectively reduced.