The invention provides a method and device for correcting a blood flow characteristic value on the basis of the plaque location. The method for correcting the blood flow characteristic value on the basis of the plaque location comprises the steps that specific geometrical parameters of an individual coronary system in the region of interest are obtained, and a geometric model and a plaque locationmodel are built; a morphological difference function f(x) in the region of interest is built on the basis of the geometric model; specific blood flow parameters of the individual coronary system in the region of interest are obtained, and by combining the geometric model of an individual in the region of interest, values such as the blood flow speed V, the blood flow pressure Pa, the first pressure difference delta P0, the second pressure difference delta P and the like which reflect blood flow characteristics in the region of interest are obtained. Accordingly, the blood flow characteristicsare corrected on the basis of the plaque locations, by introducing the concept of morphology and combining the influence of plaque position information on the blood characteristic value, the calculation result of the blood flow characteristic value can be corrected, and the accuracy of blood flow characteristic value calculation is improved.