The invention provides a dust removal shot blasting machine, and solves the problem of difficult breathing of operators caused by generation of a lot of dust during working of a traditional shot blasting machine through arrangement of a fan and a dust removing device on the shot blasting machine. Through three stages of dust removal of a first dust remover, a second dust remover and a cyclone dustremover, the dust removing effect is greatly improved, and the pollution of workshop environments by dust is prevented; the first dust remover removes the dust through collision inertia principles; afirst baffle plate and a second baffle plate are used for forming a zigzag channel to stop linear advancement of air currents; multiple first collision bars and second collision bars are used for forming multiple air current quick steering points, so that the collision frequency of the air currents with the first collision bars and the second collision bars is increased, and the separation efficiency is improved; the second dust remover uses a separation module for uniformly distributing the air currents entering the second dust remover; water forms water curtains on the surfaces of a first separation piece, a second separation piece, a third separation piece and a fourth separation piece; and water drops and the air currents relatively move to realize wet dust removal.