The invention discloses an ultra-supercritical secondary reheating tower-type boiler operation control method. The operation control method comprises the following steps that coals are put, six coal mills, two primary air fans, two air blowers, two air induced draft fans, two air pre-heaters and a boiler are started gradually, and a unit gradually rises the load to 1000 MW; primary wind speed thermal state leveling is carried out; the air opening degree of an oil layer is optimized and adjusted; the fineness of coal powder is optimized and adjusted; the opening degree of bias wind is optimizedand adjusted; the upwards and downwards swing angle of a combustor is optimized and adjusted; the upwards and downwards swing angle of SOFA air is optimized and adjusted; the air distribution mode ofthe SOFA air is optimized and adjusted; the secondary air distribution mode is optimized and adjusted; the horizontal angle of the low SOFA air is optimized and adjusted; and the running oxygen is optimized and adjusted. According to the control method, the operation mode of the ultra-supercritical secondary reheating tower-type boiler can be adjusted, hearth combustion is improved, the carbon content of fly ash and the CO concentration of the outlet of a coal economizer are reduced, the efficiency of the boiler is improved, the operation oxygen is optimized, and the economical efficiency, the safety and the environmental protection performance of the boiler are improved.