The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating endometriosis. The traditional Chinesemedicine is prepared from caulis sargentodoxae, cortex moutan radicis, radix salviae milti orrhizae, rice kernel, ostrea, rhizoma corydalis, fructus toosendan, radix dipsaci, semen cuscutae, herba epimedii, radix morindae officinalis, fructus liquidambaris, fluoritum, folium photiniae, spina gleditsiaeand fructus amomi. The invention further discloses application of the traditional Chinese medicine composition. According to clinical tests, the traditional Chinese medicine can effectively relieve patients' pain and improve vigor and emotional functions of patients, and is much superior to theWestern medicine; rat model experiments show that the traditional Chinese medicine composition can suppress VEGF and SPARC expressions to further affect new vessels of on the periphery of the endometrium and suppress growth of endometriosis and promote shrinkage thereof. The traditional Chinese medicine, prepared from traditional Chinese medicinal herbs easy to obtain, is low in cost and good in treatment effect, and is a pure traditional Chinese medicine preparation free of toxic or side effect and acceptable to patients.