The invention discloses a machining method and device for a centrifugal compressor bladed disk based on a boring mill right-angle head, and relates to the technical field of compressors. A novel machining mode for the centrifugal compressor bladed disk is provided to solve the problem that a three-axis numerical control milling machine cannot meet the requirement of the bladed disk producing cycle. The method comprises the steps that a centrifugal compressor bladed disk blank is clamped on a boring mill workbench through the boring mill cutter shaft direction changed by the boring mill right-angle head, and a rough machining cutter and a finish machining cutter are mounted on cutter connection openings of the right-angle head; the bladed disk blank is subjected to rough machining by utilizing a preset rough machining program and the rotatable properties of the rough machining cutter and the boring mill workbench; and after rough machining of the bladed disk blank, the bladed disk is subjected to finish machining by utilizing a preset finish machining program and the rotatable properties of the finish machining cutter and the boring mill workbench, so that the centrifugal compressorbladed disk is obtained. The machining method and device are suitable for machining centrifugal compressor bladed disks.