The invention provides a method for calculating multi-physical fields of a rotor based on wind path-Fluid-heat transfer synergistic coupling. The method includes the following steps: a fluid network model considering the whole rotating region of the rotor is constructed, and the pressure value of the rotor inlet and outlet is calculated as a boundary condition; the three-dimensional fluid and heattransfer analysis model of nuclear turbine generator rotor temperature field is established, and the corresponding temperature field calculation model of nuclear turbine generator rotor is established; the copper loss of the copper bar, the basic iron loss of the teeth and the additional iron loss of the nuclear turbine generator are calculated, and the losses are converted into heat densities, and the heat densities are added to the corresponding parts of the temperature field calculation model; the finite volume method is used to calculate the multi-physical field of the generator rotor. The method of the invention can calculate the wind inlet pressure and the wind outlet pressure at the rotor by using the whole-domain fluid network model, thereby effectively saving the calculation timeof the three-dimensional multi-physical field of the turbine generator rotor and improving the accuracy of the calculation.