The invention provides a composition for preventing and treating bone arthritis. The composition is characterized by comprising non-denaturing type II collagen and cartilage collagen peptide accordingto a weight ratio of 1:(0.5 to 30), preferably 1:(1 to 20), more preferably 1:(1.5 to 10), and most preferably 1:(1.5 to 6). The invention also provides application of the composition in preparationof a product for preventing and treating the bone arthritis, wherein the product is a medicine or health-care food. The composition for preventing and treating bone arthritis has the advantages that the cartilage collagen peptide can be used as a raw material needed for synthesizing cartilage tissues, the degradation of joints is prevented, and the repair function is realized on the injured joints; the non-denaturing type II collagen can inhibit the generation of inflammation, so as to relieve and treat the arthritis; proved by experiment results, the combination of the cartilage collagen peptide and the non-denaturing type II collagen can achieve a synergistic effect on the preventing and treatment of arthritis.