The invention provides a disposable and portable cotton swab with liquid medicine, which is composed of a cotton ball, a fixed claw, a connecting pipe, a liquid storage pipe and a liquid pipe, whereinthe liquid storage pipe and the connecting pipe are fixedly connected, and the connecting pipe and the fixing claw are fixedly connected, the fixing claw and the cotton ball are fixedly connected, the liquid storage pipe is a closed cavity structure, the connecting pipe is a hollow pipe structure, and the liquid pipe is fixedly disposed inside the fixing claw, the liquid pipe and the connecting pipe are connected in a thin film structure, and one end of the liquid pipe is connected with the connecting pipe, and the other end of the liquid pipe is in contact with the cotton ball. The inventionhas the advantages of adopting the mode of integrally connecting the medicinal liquid and the cotton ball, avoiding the situation that the medicinal liquid and the cotton ball are stored separately in the structural design, reducing the possibility of contamination of the medicinal liquid because the medicinal liquid is stored in a closed manner, and facilitating carrying because the medicinal liquid and the cotton ball are connected in pairs in a quantitative manner.