The invention relates to the technical field of vehicle networking, in particular to a remote control system and a method for air purification of a vehicle. The vehicle is fitted with a T-BOX module,air conditioning control system and PEPS system. The user initiates an air purification request command on the client terminal and sends the command to the T-BOX module, and then T-BOX module sends the air purification request command to the air conditioning controller, the air conditioning controller controls PM2.5 to detect the PM2.5 concentration in the current vehicle and analyze the obtainedPM2.5 concentration value. If the PM2.5 concentration value is not less than a predetermined concentration value, the air purification time can be determined according to the PM2.5 concentration value. Further, the T-BOX module controls the working time of the engine through the PEPS system according to the air purification time length, and synchronously controls the air conditioning main engine and the negative ion generator to start working to purify the air of the vehicle.