The invention discloses a detection method personalized children's drug analysis system based on SNP (single nucleotide polymorphisms) sites. SNP site combination for common anti-infection children'sdrug risk evaluation comprise 67 SNP site combinations and specific primers for detecting drug toxicity, drug metabolism and medicine reactions. Sample DNA is subjected to PCR amplification through site specific primers, the difference between a melting curve and a standard melting curve is analyzed, the Tm values of PCR amplified products are compared, and corresponding genotyping results can beobtained. The detection method can be applied to quick screening of applicability of common drugs to children, provides guide for reasonable selection of children's drugs and has the advantages of being simple to operate, high in efficiency, high in specificity, economical and the like.