The invention provides a dual-packer layered grouting water plugging device and a use method thereof. The dual-packer layered grouting water plugging device comprises a well casing, a grouting deviceand a packing device; the well casing comprises a solid tube, a water filtering tube and a outlet pipe; the grouting device comprises a mud pump, a grouting conduit and a grouting pipe; the packing device comprises a high pressure gas bottle, a high pressure gas pipeline, a decompression table, an upper packer and a lower packer; the grouting conduit extends into a cavity of the well casing; the mud pump, the grouting conduit, the upper packer, the grouting pipe and the lower packer are connected with each other in sequence; the lower end of the lower packer is connected with a bottom block; the grouting pipe corresponds to the outlet pipe in position; a rubber cylinder chamber of the upper packer and a rubber cylinder chamber of the lower packer communicate with each other through the high pressure gas pipeline B; the high pressure gas pipeline A communicates with the top of the rubber cylinder chamber of the upper packer; an inlet end of the high pressure gas pipeline A is connectedwith the decompression table; and the decompression table is connected with the high pressure gas bottle. By opening the high pressure gas bottle, the upper packer and the lower packer are inflated sothat the upper packer and the lower packer completely fit the internal wall of the solid pipe; and by using the mud pump to inject cement paste into a clearance filled with gravel packs in a water plugging position, layered water plugging is carried out.