The present invention provides an open-hole segmental fracturing differential pressure sliding sleeve, and belongs to devices used in the horizontal open-hole completion segmental fracturing process.The open-hole segmental fracturing differential pressure sliding sleeve comprises an outer cylinder and an inner sliding sleeve. The outer cylinder and the inner sliding sleeve are vertically arrangedand are cylinder-shaped bodies communicating up and down. The outer cylinder is arranged on the exterior of the inner sliding sleeve in a sleeving mode and fixedly connected with the inner sliding sleeve through a shear pin. The inner sliding sleeve comprises a first connecting part, a sliding part and a second connecting part which are sequentially arranged from top to bottom, the first connecting part and the second connecting part are in sealing fit with the inner wall of the outer cylinder, the height of the sliding part is greater than that of the first connecting part, the outer diameter of the sliding part is less than the outer diameter of the first connecting part, and a first step is formed at the bottom end of the first connecting part. An annular sliding cavity is formed by enclosing the sliding part and the inner wall of the outer cylinder, fracturing holes communicating with the sliding cavity are formed in the outer wall of the outer cylinder, and the end face of the top end of the inner sliding sleeve is arranged downward gradually in a inclination mode from outside to inside in the radial direction of the inner sliding sleeve. According to the open-hole segmentalfracturing differential pressure sliding sleeve, the opening success rate of existing differential pressure sliding sleeves can be effectively improved.