The invention provides an energy-saving management method and system of a transformer substation air conditioner. The method comprises the following steps that parameters are input, a transformer substation air conditioner working mode is set, an air conditioner control instruction is generated according to the transformer substation air conditioner working mode, and the transformer substation airconditioner working mode comprises the corresponding relation between the environment temperature in the substation and the opening number of the air conditioner in the substation; temperature data of each equipment area of the transformer substation is acquired; the environment temperature in the substation is calculated according to the temperature data of each equipment area, and the environment temperature in the substation is an average value of the temperature data of each equipment area; an in-station air conditioner control signal is generated according to the air conditioner controlinstruction and the environment temperature in the substation; and according to the control signal of the air conditioner in the substation, the air conditioner in each equipment area is controlled tobe opened or closed. The system is used for realizing the method. According to the method and the system, the technical problem that waste is caused and the service life is shortened due to over-useof an unmanned transformer substation air conditioner can be solved.