The invention provides a differential mass block type tunnel magnetoresistance accelerometer device based on a lever mechanism. The device includes an upper level tunnel magnetoresistance sensing element structure, a middle level silicon micro sensor structure, and a lower level glass substrate structure with electrode leads; and the upper structure and the middle structure are separately bonded to the lower structure through two sets of anchor points. The device combines MEMS technology and a tunnel magnetoresistance effect in quantum mechanics, is reasonable and simple in structure, is easyto process, is small in volume, and is high in measurement precision and sensitivity; the tunnel magnetoresistance effect is achieved by utilizing a change of magnetic field strength, and the magneticfield strength around a tunnel magnetoresistance element is changed by displacement of a magnetic sheet, the linearity is good, and the performance is excellent; a mass block is connected with an outer framework through the lever mechanism, when an acceleration signal is input, the mass block forms a differential motion with the outer framework; and two tunnel magnetoresistance sensing elements are symmetrically arranged in a reverse direction, an output value is reversely deviated from an initial value, differential detection is achieved, a common mode errors caused by interference is effectively inhibited, and the reliability of the device is enhanced.