The invention relates to an interlocking device of a circuit breaker and a disconnector and a high-voltage switchgear, in order to solve the problem of complex operation flow caused by adopting an electromagnetic lock to carry out anti-misoperation in the prior art. The interlocking device of the circuit breaker and the disconnector comprises a base and a shield movably mounted on the base, The shielding member has a shielding portion for shielding the manual operation shaft of the disconnector, and the interlocking device further includes a driving mechanism that drives the shielding member to operate to shield the manual operation shaft of the disconnector when the circuit breaker is closed and drives the shielding member to operate to let the manual operation shaft of the disconnector be opened when the disconnector is opened. The invention realizes the purpose of preventing the manual operation shaft of the isolation switch from being mistakenly operated by the shielding member provided with the shielding part. Compared with the case door which needs to be arranged outside the manual operation shaft of the isolation switch in the prior art, the invention is simple in operationand easy to realize automation and intellectualization.