The invention relates to a flexible load management method and a system based on a multi-agent mechanism, comprising a distribution network node agent, a distribution network clearing agent, a load aggregator, a user agent, a local management agent and a load controller agent, wherein a request/response or publish/subscribe communication mechanism is adopted between the agents. The distribution node agent formulates and publishes the daily node price based on the power supply capacity and cost of each node in the distribution network. Load aggregator agent coordinates and manages the flexibleload power of each node; User Agent makes decision on the response of flexible load; The local management agent carries out real-time constraint on the adjustment range of the flexible load; The loadcontroller agent controls the power of the flexible load; Distribution network clearing agent, load aggregator agent and user agent carry out daily fee clearing. Coordinate the work among the agents to ensure the interests of multiple parties. The invention adapts to the application requirements of flexible load, and is suitable for the management of multi-type and distributed flexible load in distribution network.