The invention discloses an efficient centring method of large and heavy spigot-free flange face equipment. The problem that centring of a spigot-free flange face is quite hard in the prior art is solved; and the effects of monitoring the horizontal centring precision and the vertical centring precision at the same time and improving centring efficiency are achieved. According to the technical scheme, the method comprises the following steps that the clearance between an equipment B flange and an equipment A flange is adjusted, and the flange face clearance can meet the set requirement; the equipment A flange and the equipment B flange are each provided with a first laser centring instrument in the vertical direction and are each provided with a second laser centring instrument in the horizontal direction; set parameters are input into the first laser centring instruments and the second laser centring instruments; the equipment A flange and the equipment B flange rotate, and the axes ofthe equipment A flange and the equipment B flange are determined; equipment A and equipment B are rotated, and after the horizontal precision is adjusted, the horizontal direction of the equipment Bis fixed; after the vertical precision is adjusted, the vertical direction of the equipment B is fixed; and the centring precision in the horizontal direction and the vertical direction is verified.