The invention relates to a method for flotation separation of lead sulfide and zinc sulfide minerals and belongs to the technical field of mineral flotation separation. The method comprises the stepsthat the pH value of ore pulp is regulated to be 8.5-10.5, zinc sulfate, sodium carbonate and ferricyanide are adopted as an inhibitor of blende, ethyl thio carbamate, xanthate and aerofloat are adopted as a collecting agent of galena, 2<#> oil is adopted as a foaming agent, and a qualified lead concentrate product is separated from the minerals; and then, copper sulfate is adopted as an activating agent of the blende, the xanthate is adopted as a collecting agent, a qualified zinc concentrate product is obtained through flotation, and thus a lead mineral and a zinc mineral are effectively separated. According to the method for flotation separation of the lead sulfide and zinc sulfide minerals, the galena and the blende can be separated through a flotation method, a reagent system is simple, the procedure is reasonable in structure, and the grade and the recovery rate of the lead and zinc minerals can be effectively increased; and a combined reagent containing the ferricyanide is adopted to inhibit the zinc mineral, the advantages of good selectivity, high inhibitive capacity, less dosage and the like are achieved, the ferricyanide is stable and has little influence on the environment, the zinc content in lead concentrates is effectively decreased under the premise of saving the reagent cost and under the precise of the low-alkali environment, and the lead mineral and the zincmineral are efficiently separated.