The invention discloses a damp-proof and shock-resistant electronic product packaging box. The damp-proof and shock-resistant electronic product packaging box comprises a base, baffles and a top cover. First grooves are formed inside the base, supporting frames are arranged inside the first grooves, and first springs are arranged between the upper ends of the supporting frames and the first grooves. A second groove is formed in the upper surface of the base, and a placement plate is arranged in the second groove. A first rubber pad is arranged on the upper surface of the second groove, secondsprings are arranged at the two ends of the placement plate, and the bottoms of the second springs are arranged on the upper surface of the base. According to the damp-proof and shock-resistant electronic product packaging box, due to the cooperative utilization of the first springs, the second springs and a limiting device, the problem that a conventional electronic product packaging box is poorin shock resistance is solved, the phenomenon that an electronic product is damaged due to the shock is avoided, and transportation of the electronic product is facilitated. Meanwhile, due to the cooperative utilization of sealing strips and a drying agent layer, the drying degree of the air inside the packaging box is improved, the phenomenon that the humid environment enables the electronic product to have short circuits is avoided, and normal operation of the electronic product is guaranteed.