The invention provides a nuclear magnetic resonance multi-dimensional spectrum method for measuring the hydrogen-hydrogen coupling constant of a specific hydrogen nucleus. The nuclear magnetic resonance multi-dimensional spectrum method comprises: applying a selective 90 DEG soft pulse while applying a Z-direction magnetic field gradient; applying a perfect echo module, and applying Z-direction magnetic field gradients with the same strength and the same direction on both sides of the selective 180 DEG soft pulse of the perfect echo; adding the 180 DEG soft pulse of an S nucleus after the first t1/2 evolution time in the second echo of the perfect echo so as to retain the J-coupling information of the S nucleus; adding the 180 DEG soft pulse of the S nucleus after the second t1/2 to compensate phase distortion; respectively applying the 180 DEG soft pulse of the selective S nucleus before the two t1/2 evolution times in the second echo so as to obtain a R type sequence corresponding toa N type sequence; and finally carrying out addition on a N type spectrum and a R type spectrum inverted along indirect dimension to obtain a phase-sensitive two-dimensional spectrum, and obtaining the corresponding J-coupling constant by measuring from the splitting of the peak in the indirect dimension.