A smart earphone device individualization system having a safe outgoing function and a use method are provided. A user downloads and installs an earphone individualization application unit into a portable device by a servo device, pairs the portable device with a smart earphone device, and then inputs corresponding data into a registration module. The user must wear the smart earphone device, detects the hearing of left and right ears through a hearing detection module and generates a detection result. An automatic compensation unit and a manual compensation module compensate the detection result. The user can adjust a sound effect mode by a preference setting module according to a personal preference to complete the individualization of the smart earphone device. The individualized smartearphone device can receive the external environment sound by a sampling unit, and then transmits the external environment sound to a sampling signal processing unit for analysis and generating an analysis signal. A central processing unit transmits the analysis signal to a signal enhancement unit for enhancement, and finally an earphone unit plays the signal to provide the user with a safe outgoing function.