The invention discloses a safe and breakage-proof conveying and packaging device for drugs. The device comprises a base, a protection cylinder and a cylinder lid; the protection cylinder comprises aninner shell and an outer shell, the inner shell is provided with an accommodating bin, and an opening part of the accommodating bin is connected with the cylinder lid; a sandwich layer is arranged between the outer shell and the inner shell, and connected with the base through the outer shell, and the base is rotatably connected with the outer shell through a sealing ring and a thread; the cylinder lid comprises an outer lid body and an inner lid body, and the inner lid body is rotatably connected with the opening part of the accommodating bin through a thread; an anti-vibration pad is arranged at the bottom of the accommodating bin. The device is novel in design, simple and reasonable in structure and safe and convenient to use, the stored drugs can be maintained at a certain temperature,and effectively prevented from being collided in the conveying or moving, or carrying process, and the thus the stored drugs can be effectively protected against damage.