The invention discloses a low-adsorption salt-resisting resistance reducing agent suitable for fracturing transformation of a shale reservoir. The low-adsorption salt-resisting resistance reducing agent is prepared from, by mass, 35-50% of a non-ionic monomer, 8-18% of a salt-resisting cationic monomer, 2-5% of a low-adsorption cationic monomer, 15-25% of a non-polar solvent, 0.7-5.5% of an emulsifying agent, 6-12% of an emulsifying auxiliary agent, 0.2-2.5% of a phase-inversion agent, 0.002-0.15% of an initiator and balance deionized water; the non-ionic monomer is a mixture of one or at least two of N,N-dimethylacrylamide, hydroxyethyl methylacrylate, lauryl methacrylate and 2-propenoicacid,2-methyl-,hexadecylester; the salt-resisting cationic monomer is dimethyl diallyl ammonium chloride or N,N-dimethylaminoethyl methacrylate or a mixture of the dimethyl diallyl ammonium chloride and the N,N-dimethylaminoethyl methacrylate; and the low-adsorption cationic monomer is quaternary ammonium salt containing polar groups. The resistance reducing agent has the advantages that the resistance reducing agent is resistant to salt and low in adsorption, and slickwater prepared from the resistance reducing agent has a small adsorption amount on the shale surface and causes little harm to the shale reservoir.