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发明公开
CN109303783A 自噬抑制剂在制备增强石蒜碱抗肝癌活性药物中的应用 有权

自噬抑制剂在制备增强石蒜碱抗肝癌活性药物中的应用
摘要：
本发明公开了自噬抑制剂在制备增强石蒜碱的抗肝癌活性药物中的应用。实验证明，石蒜碱促进了肝细胞肝癌的自噬；自噬抑制剂和石蒜碱联合用药的肝癌细胞凋亡率比自噬抑制剂单独用药的肝癌细胞凋亡率与石蒜碱单独用药的肝癌细胞凋亡率之和还要高，自噬抑制剂和石蒜碱在抗肝癌方面产生了协同作用，自噬抑制剂增强了石蒜碱的抗肝癌活性。本发明将在肝癌的治疗中发挥重要作用。
摘要（英）：

The invention discloses application of an autophagy inhibitor to preparation of a medicament for reinforcing the anti-hepatoma activity of lycorine. Experiments prove that the lycorine promotes autophagy of hepatocellular carcinoma; a hepatoma cell apoptosis rate in a case of combination of the autophagy inhibitor and the lycorine is higher than the sum of a hepatoma cell apoptosis rate in a caseof independent application of the autophagy inhibitor and a hepatoma cell apoptosis rate in a case of independent application of the lycorine; the autophagy inhibitor and the lycorine generate a synergistic effect in the aspect of resisting to hepatoma; the autophagy inhibitor reinforces the anti-hepatoma activity of the lycorine. The autophagy inhibitor can take an important effect in the treatment on hepatoma.

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