The invention relates to a valve and handcart interlocking device and a switch cabinet by using the same. The interlocking device includes a pedestal and a crank arm used for fixing a drive rotating shaft of a valve mechanism; the pedestal is movably provided with a lock piece; the lock piece has a stop position used for getting involved in a rotation path of the crank arm and being in stop fit with the crank arm to limit the rotation of the drive rotating shaft, and also has an avoidance position used for moving out from the rotation path of the crank arm and avoiding the crank arm; an elastic reset member applying the acting force moving toward the stop position to the lock piece is arranged between the lock piece and the pedestal; and the lock piece has a drive part used for being in transmission fit with a handcart to drive the lock piece to move from the stop position to the avoidance position. Thus, interlocking in place between the handcart and the valve mechanism can be realized; the mechanical and electrical properties of embedded poles can be guaranteed; and the device is simple in the whole structure and low in cost, and can enhance the product performance of the switchcabinet.