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发明授权
CN109320600B 一种基于蛋白结构域重建的新型PTH模拟肽及其应用 有权 转让

一种基于蛋白结构域重建的新型PTH模拟肽及其应用
摘要：
本发明公开了一种基于蛋白结构域重建的新型PTH(1‑34)模拟肽，该模拟肽含有第29‑34位肽片段重复，且该模拟肽第34位以及第29‑34位重复肽片段的最后一位氨基酸，由苯丙氨酸(Phenylalanine，Phe，F)改变成为酪氨酸(Tyrosine，Tyr，Y)，形成MY‑3肽，临床前期试验表明，该MY‑3模拟肽能促进成骨细胞分化，具有很好的治疗骨质疏松和促进骨生长的效果，其抗骨质疏松效果优于PTH(1‑34)(目前市场上的产品名复泰奥或特立帕肽)，具有显著的临床应用前景。
摘要（英）：

A novel PTH(1-34) mimetic peptide based on protein domain reconstruction. The mimetic peptide contains peptide fragment repeats at the 29-34th positions, and the 34th position of the mimetic peptide and the last amino acid of the peptide fragment repeats at the 29-34th positions are changed from phenylalanine (Phe, F) into tyrosine (Tyr, Y), so that MY-3 peptide is formed. Preclinical experiments show that the MY-3 mimetic peptide may promote osteoblast differentiation and has a very good effect in treating osteoporosis and promoting bone growth. The anti-osteoporosis effect of the MY-3 mimetic peptide is better than that of the PTH (1-34), so that the MY-3 mimetic peptide has a significant clinical application prospect.

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