The invention discloses a foam metal/high-entropy metal glass composite material with large compression strain and a preparing method of the foam metal/high-entropy metal glass composite material. According to the composite material, a high-entropy metal glass test bar serves as an inner base body, and the surface of the base body is wrapped by a foam layer; according to the atomic ratio, the component of the inner base body is Ti20Zr20Hf20Cu20Pd20; and according to the atomic ratio, the component of the foam layer is TiZrHfCuPd, and the foam layer is formed by stacking particles with the grain size being 0.35-0.6 micron. In the preparing method, low-concentration mixed acid is adopted, and meanwhile the two functions of dealloying and oxidization preventing are achieved;and in addition, the dealloying process and the heat treatment process are combined, residual stress of materials is effectively removed, and the layering problem is solved. The foam metal/high-entropy metal glass composite material with large compression strain and the preparing method of the foam metal/high-entropy metal glass composite material overcome the defects that current material structures and components are not uniform, energy consumption is high, and the yield is low.