The invention discloses the technical field of garbage power generation and particularly relates to a power generation device based on garbage incineration. The power generation device comprises an incineration device, a steam generation device, a water storage tank, a steam pipeline, a smoke pipeline, a turbine power generator, a condenser, a temperature difference power generation device, a smoke treating device, a chimney and a wind power turbine power generator. The steam generation device and the turbine power generator communicate through the steam pipeline. A steam outlet of the turbinepower generator and a steam inlet of the condenser communicate. The heat end of the temperature difference power generation device communicates with a smoke channel of the incineration device, and the cold end communicates with a cooling water channel. The wind power turbine power generator is arranged above the chimney. Fan blades of the wind power turbine power generator are arranged in a channel of the chimney. According to the power generation device, by arranging the turbine power generator set, the temperature difference power generation device and the wind power turbine power generator, three kinds of power generation forms are achieved, energy generated by garbage combustion is utilized fully, and the power generation device is high in efficiency and high in practicality.