The invention discloses a sand box simulation system with a high-temperature and high-pressure numerical control device. The system comprises a high-pressure gas tank group, a pressure sensor, a one-way valve, a high-pressure air pump, a high-pressure linear valve, an air channel heater, a sand box, a main control module, and a computer. The high-pressure gas tank group comprises a plurality of high-pressure gas tanks, wherein gas outlets of the high-pressure gas tank group are all connected with the pressure sensor and the high-pressure linear valve and connected with the high-pressure air pump through the one-way valve. The high-pressure linear valve is connected with the sand box through the air channel heater; the sand box is also connected with the pressure sensor. The main control module is connected with the high-pressure air pump, the sand box, and the computer. According to the sand box simulation system with the high-temperature and high-pressure numerical control device, theproblem of incapability of accurately simulating sand box material deformation in a special environment with high-temperature and high-pressure in an existing related simulation device is solved; anddata support is provided for the research of the sand box material deformation and fluid/water rock process deformation under the high-temperature and high-pressure conditions, and the deformation mechanism.