The invention provides a rapid-assembling reliable electrical and mechanical connection device, comprising an electrical connection structure, mechanical connection structures, matching designs of electrical components, and anti-loosening and anti-vibration gaskets. The electrical connection structure and the mechanical connection structures comprise horizontal connection and vertical connection according to the different arrangement conditions of equipment. According to the invention, a rapid-assembling structure is formed through the processing of sheet metal; and rivet fastening and universal gaskets are used for realizing reliable electrical connection and mechanical connection of the electrical assembly of electrical panel cabinets of electric locomotives. The device of the inventionis applicable to electrical connection and mechanical connection of electrical components with weight of 8 kg or below in electrical panel cabinets of electric locomotives, has reasonable structure, presents much better anti-loosening effect than bolt fastening, does not need frequent checking of loosening conditions, and is high in safety and reliability and convenient and fast to use; and the device improves the current situation that all the assembly of the electrical panel cabinets of electric locomotives relies on bolts and all the loosening prevention relies on identification, and avoidsthe phenomenon of the loosening of fasteners inevitably caused by long-term vibration of electric locomotives during operation in sections.