The invention relates to anti-static modified polythiophene resin and application thereof on a precise detecting instrument. The resin comprises the following ingredients: low molecular weight polyaniline, a thiophene monomer and a catalyst, wherein the number-average molar mass of the low molecular weight polyaniline is 800-3,000, and the mass ratio of the low molecular weight polyaniline to thiophene is 1-2: 8-10. The modified polythiophene resin has excellent conductivity, wherein the proportion of an HT structure can reach over 90% of the total of three mixtures.